The role of lipids in cancer progression and metastasis

• Published in: Cell metabolism Vol. 34; no. 11; pp. 1675 - 1699
• Main Authors: Martin-Perez, Miguel, Urdiroz-Urricelqui, Uxue, Bigas, Claudia, Benitah, Salvador Aznar
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2022
• Subjects: Humans; Lipid Metabolism; Lipids; metastasis; metastatic-initiating cells; Neoplasms - metabolism; Oxidative Stress; Signal Transduction; tumor storm; tumor storm; metastasis; metastatic-initiating cells; lipid metabolism

Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumo...