The role of lipids in cancer progression and metastasis

Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumo...

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Published inCell metabolism Vol. 34; no. 11; pp. 1675 - 1699
Main Authors Martin-Perez, Miguel, Urdiroz-Urricelqui, Uxue, Bigas, Claudia, Benitah, Salvador Aznar
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2022
Subjects
Humans
Lipid Metabolism
Lipids
metastasis
metastatic-initiating cells
Neoplasms - metabolism
Oxidative Stress
Signal Transduction
tumor storm
tumor storm
metastasis
metastatic-initiating cells
lipid metabolism
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Abstract Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis. [Display omitted] In this review, Martin-Perez et al. discuss recent discoveries involving the effect of lipids during cancer progression. Lipids are required for energy and membrane adaptations during the metastatic cascade but also impact cellular signaling and the tumor microenvironment, which offers distinct metabolic vulnerabilities to treat metastasis. Importantly, these lipid-mediated mechanisms seem to be potentiated when diets are enriched in fat.
AbstractList Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis.Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis.
Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis. [Display omitted] In this review, Martin-Perez et al. discuss recent discoveries involving the effect of lipids during cancer progression. Lipids are required for energy and membrane adaptations during the metastatic cascade but also impact cellular signaling and the tumor microenvironment, which offers distinct metabolic vulnerabilities to treat metastasis. Importantly, these lipid-mediated mechanisms seem to be potentiated when diets are enriched in fat.
Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of membranes); however, an excess of lipids can promote tumorigenesis, colonization, and metastatic capacity of tumor cells. To metastasize, a tumor cell goes through different stages that require lipid-related metabolic and structural adaptations. These adaptations include altering the lipid membrane composition for invading other niches and overcoming cell death mechanisms and promoting lipid catabolism and anabolism for energy and oxidative stress protective purposes. Cancer cells also harness lipid metabolism to modulate the activity of stromal and immune cells to their advantage and to resist therapy and promote relapse. All this is especially worrying given the high fat intake in Western diets. Thus, metabolic interventions aiming to reduce lipid availability to cancer cells or to exacerbate their metabolic vulnerabilities provide promising therapeutic opportunities to prevent cancer progression and treat metastasis.
Author Benitah, Salvador Aznar
Urdiroz-Urricelqui, Uxue
Bigas, Claudia
Martin-Perez, Miguel
Author_xml – sequence: 1
  givenname: Miguel
  surname: Martin-Perez
  fullname: Martin-Perez, Miguel
  email: miguel.martin@irbbarcelona.org
  organization: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
– sequence: 2
  givenname: Uxue
  surname: Urdiroz-Urricelqui
  fullname: Urdiroz-Urricelqui, Uxue
  organization: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
– sequence: 3
  givenname: Claudia
  surname: Bigas
  fullname: Bigas, Claudia
  organization: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
– sequence: 4
  givenname: Salvador Aznar
  orcidid: 0000-0002-9059-5049
  surname: Benitah
  fullname: Benitah, Salvador Aznar
  email: salvador.aznar-benitah@irbbarcelona.org
  organization: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36261043$$D View this record in MEDLINE/PubMed
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Snippet Lipids have essential biological functions in the body (e.g., providing energy storage, acting as a signaling molecule, and being a structural component of...
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SubjectTerms Humans
Lipid Metabolism
Lipids
metastasis
metastatic-initiating cells
Neoplasms - metabolism
Oxidative Stress
Signal Transduction
tumor storm
Title The role of lipids in cancer progression and metastasis
URI https://dx.doi.org/10.1016/j.cmet.2022.09.023
https://www.ncbi.nlm.nih.gov/pubmed/36261043
https://www.proquest.com/docview/2726920962
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