Comparison of adult food protein-induced enterocolitis syndrome to crustaceans and immediate-type food allergy

• Published in: Annals of allergy, asthma, & immunology Vol. 131; no. 4; pp. 487 - 493.e2
• Main Authors: Watanabe, Sho, Sato, Ayako, Uchida, Hitoshi, Kusuda, Rina, Suzuki, Hiroko, Nagashima, Saori, Yauchi, Tsunehito, Matsumoto, Kenji, Ohya, Yukihiro, Nomura, Ichiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2023
• ISSN: 1081-1206; 1534-4436
• DOI: 10.1016/j.anai.2023.06.007

Food protein-induced enterocolitis syndrome (FPIES) is increasingly found in adults. FPIES requires different treatment from immediate-type food allergy (FA) in emergency medicine. However, no comparison of the clinical presentations of these diseases has been reported. To compare the clinical presentations and causative crustaceans of adult FPIES and FA using a standardized questionnaire and to thereby lay the groundwork for establishing an algorithm that distinguishes those diseases. We conducted a retrospective cohort study of crustacean-avoidant adults by telephone interview based on the previously reported diagnostic criteria for adult FPIES to compare the clinical features and crustacean intake status between FPIES and FA. Of 73 adult patients with crustacean allergy, 8 (11%) were diagnosed with having FPIES and 53 (73%) FA. Compared with the patients with FA, those with FPIES had a longer latency period (P < .01), more episodes (P = .02), longer duration of symptoms (P = .04), more frequent abdominal distention (P = .02), and severe colic pain (P = .02). Half of the patients with FPIES experienced fear of death during an episode. Panulirus japonicus (Japanese spiny lobster) and Homarus weber (lobster) were significantly common FPIES-causing foods. A statistically significant 62.5% of patients with FPIES were able to ingest some type of crustacean. FPIES and FA can be clearly differentiated by the abdominal symptoms, latency period, and duration of episodes. Furthermore, some patients with FPIES do not necessarily need to avoid all crustaceans. Our findings lay the groundwork for establishing an algorithm that distinguishes FPIES from FA in adults.