miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing–remitting multiple sclerosis

• Published in: Gene Vol. 544; no. 2; pp. 128 - 133
• Main Authors: Honardoost, Mohammad Amin, Kiani-Esfahani, Abbas, Ghaedi, Kamran, Etemadifar, Masoud, Salehi, Mansoor
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.07.2014
• Subjects: autoimmune diseases; biomarkers; Cell Differentiation - genetics; Cell Differentiation - immunology; Female; Gene Expression Regulation; Genetic Markers; Humans; lymphocytes; Male; MicroRNA; MicroRNAs - genetics; miR-26a; miR-326; Multiple Sclerosis, Relapsing-Remitting - diagnosis; Multiple Sclerosis, Relapsing-Remitting - genetics; myelin sheath; non-coding RNA; pathogenesis; patients; quantitative polymerase chain reaction; Recurrence; relapse; Relapsing–remitting multiple sclerosis; remission; sclerosis; signal transduction; STAT1 Transcription Factor - genetics; Th-17 cells; Th17 Cells - immunology; transforming growth factor beta; Transforming Growth Factor beta - genetics; Transforming Growth Factor beta - metabolism; PP; PR; miRNAs; MS; Th-17 cells; ROC; CNS; DAVID; miR-26a; miR-326; AUC; MicroRNA; hADSCs; Relapsing–remitting multiple sclerosis; KEGG; PBLs; SP

Multiple sclerosis is an inflammatory autoimmune disease widely characterized by myelin destruction of CNS. Th-17 cells, have been demonstrated to play a crucial role in pathogenesis of MS. MicroRNAs are a new class of non-coding RNAs that participate in post-transcriptional regulation of gene expre...