Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer

• Published in: Frontiers in immunology Vol. 16; p. 1571446
• Main Authors: Jiang, Zhihang, Li, Xiaoqing, Hu, Long, Jiang, Zheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.05.2025
• Subjects: Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cell Line, Tumor; colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - immunology; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Female; Gene Expression Regulation, Neoplastic; Humans; Immunology; Male; PCED1A; Prognosis; prognostic model; Protein Processing, Post-Translational; Succinic Acid - metabolism; succinylation; Transcriptome; tumor immune microenvironment; Tumor Microenvironment - immunology; succinylation; colorectal cancer; prognostic model; tumor immune microenvironment; PCED1A

Succinylation, a key post-translational modification, plays a crucial role in metabolic regulation and tumor progression. However, its influence on the tumor immune microenvironment and its prognostic implications remain unclear. A systematic pan-cancer analysis of succinylation-related molecular ac...