A functional group-guided approach to aptamers for small molecules

• Published in: Science (American Association for the Advancement of Science) Vol. 380; no. 6648; pp. 942 - 948
• Main Authors: Yang, Kyungae, Mitchell, Noelle M, Banerjee, Saswata, Cheng, Zhenzhuang, Taylor, Steven, Kostic, Aleksandra M, Wong, Isabel, Sajjath, Sairaj, Zhang, Yameng, Stevens, Jacob, Mohan, Sumit, Landry, Donald W, Worgall, Tilla S, Andrews, Anne M, Stojanovic, Milan N
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 02.06.2023
• Subjects: Amino acids; Aptamers; Functional groups; Fungicides; Leucine; Nucleotide sequence; Nucleotides; Oligonucleotides; Optimization; Ribonucleic acid; RNA; Voriconazole

Aptameric receptors are important biosensor components, yet our ability to identify them depends on the target structures. We analyzed the contributions of individual functional groups on small molecules to binding within 27 target-aptamer pairs, identifying potential hindrances to receptor isolatio...