Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?

Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may accumulate preferentially in tissues predisposed to higher levels of oxidative stress and inflammation. Given its potent...

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Published in	Biochemical and biophysical research communications Vol. 478; no. 1; pp. 162 - 167
Main Authors	Cheah, Irwin K., Feng, Lei, Tang, Richard M.Y., Lim, Keith H.C., Halliwell, Barry
Format	Journal Article
Language	English
Published	United States Elsevier Inc 09.09.2016
Subjects	Age Distribution Aged Aged, 80 and over Ageing Aging - metabolism Antioxidant Biomarkers - blood blood cognitive disorders Cognitive Dysfunction - blood Cognitive Dysfunction - diagnosis Cognitive Dysfunction - epidemiology diet disease incidence elderly Ergothioneine Ergothioneine - blood Female Humans Incidence inflammation Middle Aged Neurodegeneration neurodegenerative diseases Neurodegenerative Diseases - blood Neurodegenerative Diseases - diagnosis Neurodegenerative Diseases - epidemiology oxidative stress Reproducibility of Results Risk Assessment - methods Risk factor Risk Factors senescence (aging) Sensitivity and Specificity Singapore - epidemiology tissues Ergothioneine MCI AD BBB PD Neurodegeneration Ageing Risk factor Hb OCTN1 Antioxidant ET
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Abstract	Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may accumulate preferentially in tissues predisposed to higher levels of oxidative stress and inflammation. Given its potential cytoprotective effects, we examined how ET levels change with age. We found that whole blood ET levels in elderly individuals decline significantly beyond 60 years of age. Additionally, a subset of these subjects with mild cognitive impairment had significantly lower plasma ET levels compared with age-matched subjects. This decline suggests that deficiency in ET may be a risk factor, predisposing individuals to neurodegenerative diseases. [Display omitted] •Blood levels of ergothioneine in elderly were found to decline with age.•Blood ergothioneine significantly declines with incidence of early dementia.•Decline not due to change in diet or expression of ergothioneine transporter.•Declining blood ergothioneine suggested to be a risk factor for neurodegeneration.
AbstractList	Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may accumulate preferentially in tissues predisposed to higher levels of oxidative stress and inflammation. Given its potential cytoprotective effects, we examined how ET levels change with age. We found that whole blood ET levels in elderly individuals decline significantly beyond 60 years of age. Additionally, a subset of these subjects with mild cognitive impairment had significantly lower plasma ET levels compared with age-matched subjects. This decline suggests that deficiency in ET may be a risk factor, predisposing individuals to neurodegenerative diseases. Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may accumulate preferentially in tissues predisposed to higher levels of oxidative stress and inflammation. Given its potential cytoprotective effects, we examined how ET levels change with age. We found that whole blood ET levels in elderly individuals decline significantly beyond 60 years of age. Additionally, a subset of these subjects with mild cognitive impairment had significantly lower plasma ET levels compared with age-matched subjects. This decline suggests that deficiency in ET may be a risk factor, predisposing individuals to neurodegenerative diseases.Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may accumulate preferentially in tissues predisposed to higher levels of oxidative stress and inflammation. Given its potential cytoprotective effects, we examined how ET levels change with age. We found that whole blood ET levels in elderly individuals decline significantly beyond 60 years of age. Additionally, a subset of these subjects with mild cognitive impairment had significantly lower plasma ET levels compared with age-matched subjects. This decline suggests that deficiency in ET may be a risk factor, predisposing individuals to neurodegenerative diseases. Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific transporter, OCTN1, ET may accumulate preferentially in tissues predisposed to higher levels of oxidative stress and inflammation. Given its potential cytoprotective effects, we examined how ET levels change with age. We found that whole blood ET levels in elderly individuals decline significantly beyond 60 years of age. Additionally, a subset of these subjects with mild cognitive impairment had significantly lower plasma ET levels compared with age-matched subjects. This decline suggests that deficiency in ET may be a risk factor, predisposing individuals to neurodegenerative diseases. [Display omitted] •Blood levels of ergothioneine in elderly were found to decline with age.•Blood ergothioneine significantly declines with incidence of early dementia.•Decline not due to change in diet or expression of ergothioneine transporter.•Declining blood ergothioneine suggested to be a risk factor for neurodegeneration.
Author	Lim, Keith H.C. Halliwell, Barry Tang, Richard M.Y. Feng, Lei Cheah, Irwin K.
Author_xml	– sequence: 1 givenname: Irwin K. surname: Cheah fullname: Cheah, Irwin K. organization: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore – sequence: 2 givenname: Lei surname: Feng fullname: Feng, Lei organization: Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore 119228, Singapore – sequence: 3 givenname: Richard M.Y. surname: Tang fullname: Tang, Richard M.Y. organization: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore – sequence: 4 givenname: Keith H.C. surname: Lim fullname: Lim, Keith H.C. organization: Department of Radiation Oncology, National University Cancer Institute Singapore, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore – sequence: 5 givenname: Barry surname: Halliwell fullname: Halliwell, Barry email: bchbh@nus.edu.sg organization: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore
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Keywords	Ergothioneine MCI AD BBB PD Neurodegeneration Ageing Risk factor Hb OCTN1 Antioxidant ET
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Snippet	Ergothioneine (ET), a naturally occurring thione, can accumulate in the human body at high concentrations from diet. Following absorption via a specific...
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SubjectTerms	Age Distribution Aged Aged, 80 and over Ageing Aging - metabolism Antioxidant Biomarkers - blood blood cognitive disorders Cognitive Dysfunction - blood Cognitive Dysfunction - diagnosis Cognitive Dysfunction - epidemiology diet disease incidence elderly Ergothioneine Ergothioneine - blood Female Humans Incidence inflammation Middle Aged Neurodegeneration neurodegenerative diseases Neurodegenerative Diseases - blood Neurodegenerative Diseases - diagnosis Neurodegenerative Diseases - epidemiology oxidative stress Reproducibility of Results Risk Assessment - methods Risk factor Risk Factors senescence (aging) Sensitivity and Specificity Singapore - epidemiology tissues
Title	Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration?
URI	https://dx.doi.org/10.1016/j.bbrc.2016.07.074 https://www.ncbi.nlm.nih.gov/pubmed/27444382 https://www.proquest.com/docview/1810069130 https://www.proquest.com/docview/1815700799 https://www.proquest.com/docview/2131858266
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