Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma

• Published in: Cancer research (Chicago, Ill.) Vol. 76; no. 24; pp. 7140 - 7150
• Main Authors: Chang, Wei-Min, Lin, Yuan-Feng, Su, Chia-Yi, Peng, Hsuan-Yu, Chang, Yu-Chan, Lai, Tsung-Ching, Wu, Guan-Hsun, Hsu, Yuan-Ming, Chi, Li-Hsing, Hsiao, Jenn-Ren, Chen, Chi-Long, Chang, Jang-Yang, Shieh, Yi-Shing, Hsiao, Michael, Shiah, Shine-Gwo
• Format: Journal Article
• Language: English
• Published: United States 15.12.2016
• Subjects: Animals; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Chromatin Immunoprecipitation; Core Binding Factor Alpha 1 Subunit - metabolism; Down-Regulation; Female; Gene Expression Regulation, Neoplastic - physiology; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Humans; In Situ Hybridization; Inhibin-beta Subunits - metabolism; Lymphatic Metastasis; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs - biosynthesis; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Signal Transduction - physiology; Squamous Cell Carcinoma of Head and Neck; Tissue Array Analysis

Epigenetic correlates of the head and neck cancer may illuminate its pathogenic roots. Through a gene set enrichment analysis, we found that the oncogenic transcription factor RUNX2 is widely upregulated in the head and neck squamous cell carcinoma (HNSCC) with lymph node metastasis, where it also p...