Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway by manganese chloride

• Published in: Toxicology and applied pharmacology Vol. 336; pp. 94 - 100
• Main Authors: Zhang, Zhipeng, Guo, Zhenkun, Zhan, Yanting, Li, Huangyuan, Wu, Siying
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2017
• Subjects: Acetylation; Active Transport, Cell Nucleus; Anacardic Acids - pharmacology; Animals; Chlorides - toxicity; Glutathione - metabolism; Heme Oxygenase (Decyclizing) - metabolism; Heme oxygenase-1(HO-1); Histone acetylation; Histone Deacetylase Inhibitors - pharmacology; Histones - metabolism; Hydroxamic Acids - pharmacology; Manganese chloride; Manganese Compounds; Manganese Poisoning - drug therapy; Manganese Poisoning - enzymology; Manganese Poisoning - etiology; Manganese Poisoning - genetics; Neurons - drug effects; Neurons - enzymology; Neurotoxicity; NF-E2-related factor 2 (Nrf2); NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; PC12 Cells; Rats; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; AA; TSA; HRP; Histone acetylation; HO-1; PC12; Neurotoxicity; NF-E2-related factor 2 (Nrf2); PD; ARE; Nrf2; ROS; Heme oxygenase-1(HO-1); HAT; GSH; Manganese chloride; HDAC

Manganese neurotoxicity is characterized by Parkinson-like symptoms with degeneration of dopaminergic neurons in the basal ganglia as the principal pathological feature. Manganese neurotoxicity studies may contribute to a good understanding of the mechanism of Parkinson's disease (PD). In this...