Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939—an oral, direct Factor Xa inhibitor—after multiple dosing in healthy male subjects - Kubitza, Dagmar; Becka, Michael; Wensing, Georg; Voith, Barbara; Zuehlsdorf, Michael (European journal of clinical pharmacology, 2005)
Keywords: Administration, Oral; Adult; Antithrombin III - adverse effects; Antithrombin III - pharmacokinetics; Antithrombin III - pharmacology; Area Under Curve; Biological and medical sciences; Half-Life; Humans; Male; Medical sciences; Middle Aged; Morpholines - adverse effects; Morpholines - pharmacokinetics; Morpholines - pharmacology; Pharmacology. Drug treatments; Rivaroxaban; Single-Blind Method; Thiophenes - adverse effects; Thiophenes - pharmacokinetics; Thiophenes - pharmacology; Human; Serine endopeptidases; Healthy subject; Enzyme; Toxicity; Oral administration; Coagulation Factor Xa; Posology; Biological activity; Peptidases; Hydrolases; Inhibitor; Safety; Pharmacokinetics