Expression of decorin and collagens I and III in different layers of human skin in vivo : a laser capture microdissection study

• Published in: Biogerontology (Dordrecht) Vol. 8; no. 3; pp. 269 - 282
• Main Authors: LOCHNER, Katrin, GAEMLICH, Astrid, GALLINAT, Stefan, SIIDEL, Kirstin Marie, VENZKE, Kirsten, MOLL, Ingrid, KNOTT, Anja, STÄB, Franz, WENCK, Horst, DÖRING, Olaf, BÖTTGER, Michael
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.06.2007; Springer Nature B.V
• Subjects: Adult; Aged; Aging; Aging - genetics; Aging - metabolism; Aging - radiation effects; Biological and medical sciences; Biopsy; Cells, Cultured; Collagen; Collagen Type I - genetics; Collagen Type I - metabolism; Collagen Type III - genetics; Collagen Type III - metabolism; Decorin; Dermis; Development. Metamorphosis. Moult. Ageing; Epidermis; Extracellular matrix; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Fibroblasts - metabolism; Fibroblasts - pathology; Fibroblasts - radiation effects; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Humans; Lasers; Mechanical properties; Microdissection - methods; Middle Aged; Proteoglycans; Proteoglycans - genetics; Proteoglycans - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Skin; Skin - metabolism; Skin - pathology; Skin - radiation effects; Studies; Ultraviolet radiation; Ultraviolet Rays; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; In vivo; Vertebrata; Senescence; Mammalia; Collagen; Glycoprotein; Extracellular matrix; Skin; Human· Photoaging; Collagen Decorin· Extracellular matrix

Extracellular matrix (ECM) organization is a complex process that requires the coordinated efforts of many molecules. For the regulation of collagen fiber diameter, the proteoglycan decorin appears to be of major relevance. To investigate the role of decorin in the process of (photo-)aging in more d...