Chemical modification of temoporfin--a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

• Published in: Chemical communications (Cambridge, England) Vol. 50; no. 81; pp. 12150 - 12153
• Main Authors: Yu, Q, Rodriguez, E M, Naccache, R, Forgione, P, Lamoureux, G, Sanz-Rodriguez, F, Scheglmann, D, Capobianco, J A
• Format: Journal Article
• Language: English
• Published: England 18.10.2014
• Subjects: Activated; Cell death; Cell Survival - drug effects; HeLa Cells; Humans; Infrared Rays; Irradiation; Mesoporphyrins - chemistry; Nanoparticles; Nanoparticles - chemistry; Nanostructure; Photosensitizing Agents - chemical synthesis; Photosensitizing Agents - chemistry; Photosensitizing Agents - toxicity; Singlet oxygen; Singlet Oxygen - chemistry; Singlet Oxygen - metabolism

LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue a...