Mitochondrial reactive oxygen species in physiology and disease

• Published in: Cell calcium (Edinburgh) Vol. 94; p. 102344
• Main Authors: Antonucci, Salvatore, Di Lisa, Fabio, Kaludercic, Nina
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2021
• Subjects: Calcium; Mitochondria; Oxidative stress; Reactive oxygen species; RET; Oxidative stress; Reactive oxygen species; CoQ; DH; IP3R; Calcium; ANT; CypD; HIF-1α; α-KGDH; I/R; PTP; Mitochondria; ΔΨm; Mn-SOD; PI3K; NNT; PDH; Prx; SOCE; MitoK; mROS; Trx; SR; TrxR; RyR2; IMM; RISK; cyt c; GR; ER; GPx; IMS; OMM; BCKDH; DHODH; CsA; TCA; ETC; NOX; MAO; mGPDH; ETF:Q; IPC; MCU

[Display omitted] •mROS act as second messengers and their formation and elimination is finely tuned.•mROS regulate several physiological processes.•Exacerbated mROS formation is a common denominator in pathological conditions.•The interplay between mROS and Ca2+ is critical in cell pathophysiology....