HDAC11 Regulates Glycolysis through the LKB1/AMPK Signaling Pathway to Maintain Hepatocellular Carcinoma Stemness

• Published in: Cancer research (Chicago, Ill.) Vol. 81; no. 8; pp. 2015 - 2028
• Main Authors: Bi, Lei, Ren, Yidan, Feng, Maoxiao, Meng, Peng, Wang, Qin, Chen, Weiping, Jiao, Qinlian, Wang, Yuli, Du, Lutao, Zhou, Fuqiong, Jiang, Yucui, Chen, Feiyan, Wang, Chuanxin, Tang, Bo, Wang, Yunshan
• Format: Journal Article
• Language: English
• Published: United States 15.04.2021

Hepatocellular carcinoma (HCC) contains a subset of cancer stem cells (CSC) that cause tumor recurrence, metastasis, and chemical resistance. Histone deacetylase 11 (HDAC11) mediates diverse immune functions and metabolism, yet little is known about its role in HCC CSCs. In this study, we report tha...