Forsythia suspensa leaf fermented tea extracts attenuated oxidative stress in mice via the Ref-1/HIF-1α signal pathway and modulation of gut microbiota

• Published in: Scientific reports Vol. 15; no. 1; pp. 4106 - 14
• Main Authors: Li, Lijuan, zhao, Yating, Ding, Yuxin, Guo, Lanze, Dai, Ruiyao, Chen, Aixiang, Duan, Guofeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/45; 692/699/1503; 692/699/1503/1702; Animals; Animals, Outbred Strains; Antioxidants; Antioxidants - pharmacology; Apoptosis; Digestive system; Epithelial cells; Fermentation; Flavonoids; Forsythia - chemistry; Forsythia suspensa; Forsythia suspensa leaf fermented tea extract (FSLFT); Gastrointestinal Microbiome - drug effects; Gastrointestinal tract; Glycosides; Gut microbiota; Humanities and Social Sciences; Hydrogen Peroxide; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Hypoxia-inducible factor 1a; Intestinal absorption; Intestinal flora; Intestinal microflora; Leaves; Male; Mice; Microbiota; multidisciplinary; NF-κB protein; Oxidative stress; Oxidative Stress - drug effects; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Redox factor-1; Ref-1/HIF-1α; Rutin; Science; Science (multidisciplinary); Signal transduction; Signal Transduction - drug effects; Small intestine; Tea - chemistry; TLR4 protein; TLR4/NF-κB; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Oxidative stress; Intestinal flora; Ref-1/HIF-1α; leaf fermented tea extract (FSLFT); TLR4/NF-κB; Forsythia suspensa leaf fermented tea extract (FSLFT)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-025-87182-6

Forsythia suspensa leaf fermented tea (FSLFT) is made from tender buds of Forsythia suspensa collected in spring. The main active components of FSLFT include forsythiaside, forsythia ester glycoside, rutin, and forsythia flavonoids, which have antibacterial, antioxidant, liver-protective, and immune...