GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates

• Published in: Cell metabolism Vol. 32; no. 6; pp. 938 - 950.e6
• Main Authors: Breen, Danna M., Kim, Hanna, Bennett, Donald, Calle, Roberto A., Collins, Susie, Esquejo, Ryan M., He, Tao, Joaquim, Stephanie, Joyce, Alison, Lambert, Matthew, Lin, Laura, Pettersen, Betty, Qiao, Shuxi, Rossulek, Michelle, Weber, Gregory, Wu, Zhidan, Zhang, Bei B., Birnbaum, Morris J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2020
• Subjects: chemotherapy; cisplatin; emesis; growth differentiation factor 15; survival; weight loss; weight loss; emesis; cisplatin; growth differentiation factor 15; chemotherapy; survival

Platinum-based cancer therapy is restricted by dose-limiting side effects and is associated with elevation of growth differentiation factor 15 (GDF-15). But whether this elevation contributes to such side effects has been unclear. Here, we explored the effects of GDF-15 blockade on platinum-based ch...