Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand - Demizu, Yosuke; Shibata, Norihito; Hattori, Takayuki; Ohoka, Nobumichi; Motoi, Hiromi; Misawa, Takashi; Shoda, Takuji; Naito, Mikihiko; Kurihara, Masaaki (Bioorganic & medicinal chemistry letters, 2016)
Keywords: BCR-ABL; Bestatin; Chemistry; Chemistry, Medicinal; Chemistry, Organic; E3 ubiquitin ligase; Fusion Proteins, bcr-abl - metabolism; Humans; Imatinib; Imatinib Mesylate - metabolism; Inhibitor of Apoptosis Proteins - metabolism; K562 Cells; Life Sciences & Biomedicine; Ligands; Pharmacology & Pharmacy; Physical Sciences; Protein Binding; Protein knockdown; Proteolysis; Science & Technology; Protein knockdown; Imatinib; E3 ubiquitin ligase; Bestatin; BCR-ABL; DESIGN; HYBRID MOLECULES; TYROSINE KINASE; ALPHA; CHRONIC MYELOID-LEUKEMIA; CELL-DEATH; SMALL-MOLECULE PROTACS; UBIQUITINATION; PHILADELPHIA-CHROMOSOME