Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury

• Published in: Journal of applied physiology (1985) Vol. 133; no. 3; pp. 585 - 592
• Main Authors: Tas, Jeanette, Bos, Kirsten D. J., Le Feber, Joost, Beqiri, Erta, Czosnyka, Marek, Haeren, Roel, van der Horst, Iwan C. C., van Kuijk, Sander M. J., Strauch, Ulrich, Brady, Ken M., Smielewski, Peter, Aries, Marcel J. H.
• Format: Journal Article
• Language: English
• Published: Bethesda American Physiological Society 01.09.2022
• Subjects: Animal models; Blood pressure; Brain; Head injuries; Injury prevention; Innovative Methodology; Intracranial pressure; Monitoring; Oscillations; Patients; Perfusion; Physiology; Telemedicine; Traumatic brain injury; Variability

Cerebral autoregulation assessment requires sufficient slow arterial blood pressure (ABP) waves. However, spontaneous ABP waves may be insufficient for reliable cerebral autoregulation estimations. Therefore, we applied a ventilator “sigh-function” to generate positive end-expiratory pressure oscill...