A simple high performance liquid chromatography–mass spectrometry method for Therapeutic Drug Monitoring of isavuconazole and four other antifungal drugs in human plasma samples

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 145; pp. 718 - 724
• Main Authors: Fatiguso, Giovanna, Favata, Fabio, Zedda, Ilaria, De Nicolò, Amedeo, Cusato, Jessica, Avataneo, Valeria, Di Perri, Giovanni, D’Avolio, Antonio
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 25.10.2017
• Subjects: Antifungal Agents; Antifungal drugs; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Isavuconazole; LC–MS; Matrix effects; Nitriles; Pyridines; Tandem Mass Spectrometry; Triazole; Triazoles; Voriconazole; Matrix effects; Triazole; Isavuconazole; Voriconazole; LC–MS; Antifungal drugs

Overlaid chromatograms showing the retention times of Fluconazole (FLU), Voriconazole (VRC), Posaconazole (PSC), Isavuconazole (ISC), Itraconazole (ITC) and their corresponding internal standards in a calibration standard sample. [Display omitted] •Simple HPLC–MS method to quantify 5 antifungal tria...