Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs - Maekawa, Naoya; Konnai, Satoru; Watari, Kei; Takeuchi, Hiroto; Nakanishi, Takeshi; Tachibana, Taro; Hosoya, Kenji; Kim, Sangho; Kinoshita, Ryohei; Owaki, Ryo; Yokokawa, Madoka; Kagawa, Yumiko; et al. (Frontiers in immunology, 2025)
Keywords: Animals; Antibodies, Monoclonal - pharmacology; Antibodies, Monoclonal - therapeutic use; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - immunology; canine tumor; CTLA-4 Antigen - antagonists & inhibitors; CTLA-4 Antigen - immunology; cytotoxic T lymphocyte associated protein 4 (CTLA-4); Dog Diseases - drug therapy; Dog Diseases - immunology; Dogs; Female; immune checkpoint inhibitors; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunology; Immunotherapy; Male; Neoplasms - drug therapy; Neoplasms - immunology; Neoplasms - veterinary; programmed death ligand 1 (PD-L1); Salvage Therapy; canine tumor; programmed death ligand 1 (PD-L1); immune checkpoint inhibitors; cytotoxic T lymphocyte associated protein 4 (CTLA-4); immunotherapy