Disease association study of Autoimmune and autoinflammatory diseases by integrating multi-modal data and hierarchical ontologies

• Published in: Frontiers in immunology Vol. 16; p. 1575490
• Main Authors: Liu, Axian, Su, Yutong, Zhu, Jinwei, Li, Yuan-Yuan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.06.2025
• Subjects: autoimmune diseases; Autoimmune Diseases - etiology; Autoimmune Diseases - genetics; Autoimmune Diseases - immunology; autoinflammatory diseases; Biological Ontologies; Computational Biology - methods; disease association; diseasome; Hereditary Autoinflammatory Diseases - genetics; Humans; Immunology; Inflammation; multi-modal data integration; ontology; autoimmune diseases; multi-modal data integration; disease association; ontology; autoinflammatory diseases; diseasome

Autoimmune and autoinflammatory diseases (AIIDs) are characterized by significant heterogeneity and comorbidities, complicating their mechanisms and classification. Disease associations studies, or diseasome, facilitate the exploration of disease mechanisms and development of novel therapeutic strat...