Long-term quality of life outcomes in three antiretroviral treatment strategies for HIV-1 infection

• Published in: AIDS (London) Vol. 15; no. 15; pp. 1985 - 1991
• Main Authors: NIEUWKERK, Pythia T, GISOLF, Elisabeth H, REIJERS, Monique H. E, LANGE, Joep M. A, DANNER, Sven A, SPRANGERS, Mirjam A. G
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 19.10.2001
• Subjects: Adult; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; antiretroviral therapy; Antiretroviral Therapy, Highly Active; Antiviral agents; Biological and medical sciences; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections - drug therapy; HIV Infections - virology; HIV-1 - drug effects; HIV-1 - physiology; Human immunodeficiency virus 1; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Middle Aged; nelfinavir; Pharmacology. Drug treatments; Quality of Life; Reverse Transcriptase Inhibitors - administration & dosage; Reverse Transcriptase Inhibitors - therapeutic use; RNA, Viral - blood; Time Factors; Treatment Outcome; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Purine nucleoside; Prognosis; RNA-directed DNA polymerase; HIV-1 virus; Ritonavir; Stavudine; Saquinavir; Reverse transcriptase inhibitor; Nelfinavir; Antiviral; Pyrimidine nucleoside; Human; Immunopathology; Drug combination; Enzyme; Transferases; Retroviridae; Enzyme inhibitor; Lamivudine; AIDS; Immune deficiency; Lentivirus; Long term; Quality of life; Infection; Virus; Peptidases; Nucleotidyltransferases; Chemotherapy; Treatment; Viral disease; Dideoxynucleoside; Hydrolases; Human immunodeficiency virus; Didanosine; Therapeutic protocol; Zidovudine; Comparative study; Protease inhibitor

To compare changes in quality of life (QoL) over 96 weeks in patients enrolled in a triple-therapy protocol, a treatment-intensification protocol, or an induction-maintenance therapy protocol, and to compare QoL between patients who continued and discontinued their antiretroviral regimen. Naive pati...