Granulocyte colony-stimulating factor-associated aortitis in the Japanese Adverse Drug Event Report database

• Published in: Cytokine (Philadelphia, Pa.) Vol. 119; pp. 47 - 51
• Main Authors: Oshima, Yasuo, Takahashi, Satoshi, Tani, Kenzaburo, Tojo, Arinobu
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2019
• Subjects: Adverse event; Aortitis; Big data; Granulocyte colony-stimulating factor (G-CSF); Japanese Adverse Drug Event Report; Real world evidence (RWE); RWE; AE; EPO; Adverse event; JADER; G-CSF; BCPNN; ADR; EPPV; Granulocyte colony-stimulating factor (G-CSF); RMP; MAH; Japanese Adverse Drug Event Report; DUI; Aortitis; Big data; Real world evidence (RWE); PMDA

•Anecdotal case reports have suggested association between G-CSF and aortitis.•Relationship between G-CSF and aortitis had remained unclear.•Japanese pharmacovigilance database JADER harbors 102,014 subjects with malignancies.•The adjusted odds ratio for aortitis in the malignancy cases with G-CSF w...