Methylene blue protects the cortical blood-brain barrier against ischemia/reperfusion-induced disruptions

• Published in: Critical care medicine Vol. 38; no. 11; p. 2199
• Main Authors: Miclescu, Adriana, Sharma, Hari Shanker, Martijn, Cécile, Wiklund, Lars
• Format: Journal Article
• Language: English
• Published: United States 01.11.2010
• Subjects: Animals; Blood-Brain Barrier - drug effects; Blotting, Western; Brain Ischemia - etiology; Brain Ischemia - metabolism; Brain Ischemia - physiopathology; Cardiopulmonary Resuscitation; Cerebral Cortex - chemistry; Cerebral Cortex - metabolism; Heart Arrest - complications; Methylene Blue - pharmacology; Nitrates - analysis; Nitric Oxide Synthase - drug effects; Nitric Oxide Synthase - metabolism; Nitrites - analysis; Oxygen - metabolism; Reperfusion Injury - metabolism; Reperfusion Injury - physiopathology; Reperfusion Injury - prevention & control; Swine; Water-Electrolyte Balance

To investigate the effects of cardiac arrest and the reperfusion syndrome on blood-brain barrier permeability and evaluate whether methylene blue counteracts blood-brain barrier disruption in a pig model of controlled cardiopulmonary resuscitation. Randomized, prospective, laboratory animal study. U...