Increased Reticulon 3 (RTN3) Leads to Obesity and Hypertriglyceridemia by Interacting With Heat Shock Protein Family A (Hsp70) Member 5 (HSPA5)

• Published in: Circulation (New York, N.Y.) Vol. 138; no. 17; pp. 1828 - 1838
• Main Authors: Xiang, Rong, Fan, Liang-liang, Huang, Hao, Chen, Ya-qin, He, Wanxia, Guo, Shuai, Li, Jing-Jing, Jin, Jie-yuan, Du, Ran, Yan, Riqiang, Xia, Kun
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 23.10.2018
• Subjects: 3T3-L1 Cells; Adipose Tissue - metabolism; Adolescent; Adult; AMP-Activated Protein Kinases; Animals; Biomarkers - blood; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Carrier Proteins - blood; Carrier Proteins - genetics; Case-Control Studies; Female; Genetic Predisposition to Disease; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; Humans; Hypertriglyceridemia - blood; Hypertriglyceridemia - diagnosis; Hypertriglyceridemia - genetics; Lipid Droplets - metabolism; Male; Membrane Proteins - blood; Membrane Proteins - genetics; Mice; Mice, Knockout; Middle Aged; Nerve Tissue Proteins - blood; Nerve Tissue Proteins - deficiency; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Obesity - blood; Obesity - diagnosis; Obesity - genetics; Phenotype; Sterol Regulatory Element Binding Protein 1 - metabolism; Triglycerides - blood; Up-Regulation; Young Adult; hypertriglyceridemia; HSPA5 protein; lipid droplets; RTN3 protein, human; obesity
• ISSN: 0009-7322; 1524-4539; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.117.030718

BACKGROUND:Reticulon 3 (RTN3) is an endoplasmic reticulum protein that has previously been shown to play a role in neurodegenerative diseases, but little is known about its role in lipid metabolism. METHODS:Obese patients (n=149), hypertriglyceridemic patients (n=343), and healthy control subjects (...