Copper(I) Phosphide Nanocrystals for In Situ Self‐Generation Magnetic Resonance Imaging‐Guided Photothermal‐Enhanced Chemodynamic Synergetic Therapy Resisting Deep‐Seated Tumor

• Published in: Advanced functional materials Vol. 29; no. 50
• Main Authors: Liu, Yang, Wu, Junduo, Jin, Yinhua, Zhen, Wenyao, Wang, Yinghui, Liu, Jianhua, Jin, Longhai, Zhang, Songtao, Zhao, Ying, Song, Shuyan, Yang, Yang, Zhang, Hongjie
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.12.2019
• Subjects: Antioxidants; Apoptosis; Copper; copper(I) phosphide; Fenton‐like reactions; Glutathione; Hydrogen peroxide; Hydroxyl radicals; in situ self‐generation MRI; Magnetic resonance imaging; Materials science; Medical imaging; Nanocrystals; NIR‐II biowindows; NMR; Nuclear magnetic resonance; Phosphides; Photothermal conversion; photothermal therapy; Therapy; Tumors

Fe‐based Fenton agents can generate highly reactive and toxic hydroxyl radicals (·OH) in the tumor microenvironment (TME) for chemodynamic therapy (CDT) with high specificity. However, the strict condition (lower pH environment: 3–4) of the highly efficient Fenton reaction limits its practical appli...