TOTUM‐63, a plant‐based polyphenol‐rich extract, improves glycaemic control in subjects with prediabetes or early stage newly‐diagnosed type 2 diabetes in a randomized, double‐blind, placebo‐controlled trial

• Published in: Diabetes, obesity & metabolism Vol. 24; no. 12; pp. 2331 - 2340
• Main Authors: Sirvent, Pascal, Chavanelle, Vivien, Otero, Yolanda F., Bargetto, Maxime, Le Joubioux, Florian, Boisseau, Nathalie, Maugard, Thierry, Cazaubiel, Murielle, Pereira, Bruno, Guigas, Bruno, Hadjadj, Samy, Peltier, Sebastien L., Marette, André, Bard, Jean‐Marie
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2022; Wiley Subscription Services, Inc; Wiley
• Subjects: Aged; Blood glucose; Blood Glucose - metabolism; Blood levels; Body mass index; Body weight; Body weight gain; botanical extract; Cholesterol; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; diabetic; Double-Blind Method; Double-blind studies; Drug therapy; Fasting; Female; Glucose; Glucose tolerance; glycaemia; Glycemic Control; Homeostasis; Humans; Intolerance; Life Sciences; Male; Medical diagnosis; Metabolic syndrome; Middle Aged; Obesity; Obesity - complications; Obesity - drug therapy; Overweight; Overweight - complications; Overweight - drug therapy; Placebos; Plant extracts; Plant Extracts - therapeutic use; Polyphenols - therapeutic use; prediabetic; Prediabetic State - diagnosis; Prediabetic State - drug therapy; TOTUM‐63; Triglycerides; weight management; metabolic syndrome; diabetic; prediabetic; weight management; botanical extract; glycaemia; TOTUM-63

Aim The plant‐based polyphenol‐rich extract TOTUM‐63 improves glucose homeostasis in various preclinical models of obesity and type 2 diabetes (T2D). A pilot exploratory study showed that TOTUM‐63 has good safety and tolerability profiles, and beneficial effects on postprandial glucose control in he...