Control of transient, resurgent, and persistent current by open-channel block by Na channel β4 in cultured cerebellar granule neurons

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 27; pp. 12357 - 12362
• Main Authors: Bant, Jason S, Raman, Indira M
• Format: Journal Article
• Language: English
• Published: National Academy of Sciences 06.07.2010; National Acad Sciences
• Subjects: action potentials; Biological Sciences; cerebellum; Cultured cells; Electric current; Electric potential; electric power; heterologous gene expression; Kinetics; Neurons; Neuroscience; phenotype; reverse transcriptase polymerase chain reaction; Small interfering RNA; Sodium; Sodium channels; Transfection

Voltage-gated Na channels in several classes of neurons, including cells of the cerebellum, are subject to an open-channel block and unblock by an endogenous protein. The NaVβ4 (Scn4b) subunit is a candidate blocking protein because a free peptide from its cytoplasmic tail, the β4 peptide, can block...