Pharmacokinetic-pharmacodynamic crossover comparison of two levodopa extension strategies - LeWitt, Peter A.; Jennings, Danna; Lyons, Kelly E.; Pahwa, Rajesh; Rabinowicz, Adrian L.; Wang, James; Guarnieri, Maria; Hubble, Jean P.; Murck, Harold (Movement disorders, 2009)
Keywords: Aged; Analysis of Variance; Antiparkinson Agents - blood; Antiparkinson Agents - pharmacokinetics; Antiparkinson Agents - therapeutic use; Biological and medical sciences; Carbidopa - pharmacokinetics; Carbidopa - therapeutic use; Catechols - pharmacokinetics; Catechols - therapeutic use; Cross-Over Studies; Disability Evaluation; Dose-Response Relationship, Drug; Drug Delivery Systems - classification; Drug Delivery Systems - methods; Drug Therapy, Combination; Drug toxicity and drugs side effects treatment; entacapone; Female; Humans; levodopa; Levodopa - blood; Levodopa - pharmacokinetics; Levodopa - therapeutic use; Male; Medical sciences; Middle Aged; motor fluctuation; Neurology; Nitriles - pharmacokinetics; Nitriles - therapeutic use; Parkinson Disease - blood; Parkinson Disease - drug therapy; Parkinson's disease; pharmacodynamics; pharmacokinetics; Pharmacology. Drug treatments; Retrospective Studies; Severity of Illness Index; Time Factors; Toxicity: nervous system and muscle; Fluctuations; Nervous system diseases; Pharmacodynamics; Parkinson's disease; motor fluctuation; Parkinson disease; Cerebral disorder; Central nervous system disease; Entacapone; Strategy; Degenerative disease; Levodopa; Pharmacokinetics; Comparative study; Extrapyramidal syndrome