Inhibition of S-Adenosylhomocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway - Xiao, Yunjun; Xia, Junjie; Cheng, Jinquan; Huang, Haiyan; Zhou, Yani; Yang, Xifei; Su, Xuefen; Ke, Yuebin; Ling, Wenhua (Circulation (New York, N.Y.), 2019)
Keywords: Adenosine - administration & dosage; Adenosine - analogs & derivatives; Adenosine - pharmacology; Adenosylhomocysteinase - antagonists & inhibitors; Adenosylhomocysteinase - genetics; Adenosylhomocysteinase - metabolism; Aged; Animals; Atherosclerosis - metabolism; Coronary Artery Disease - metabolism; Disease Models, Animal; DNA Methylation; Endothelium, Vascular - physiology; Epigenesis, Genetic; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout, ApoE; Middle Aged; Oxidative Stress; RNA, Small Interfering - genetics; S-Adenosylhomocysteine - blood; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1 - genetics; Src Homology 2 Domain-Containing, Transforming Protein 1 - metabolism; endothelium; methyltransferases; epigenesis, genetic; S-Adenosylhomocysteine; oxidative stress