From Diagnosis to Prognosis: Revisiting the Meaning of Muscle ISG15 Overexpression in Juvenile Inflammatory Myopathies

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 73; no. 6; pp. 1044 - 1052
• Main Authors: Hou, Cyrielle, Durrleman, Chloé, Periou, Baptiste, Barnerias, Christine, Bodemer, Christine, Desguerre, Isabelle, Quartier, Pierre, Melki, Isabelle, Rice, Gillian I., Rodero, Mathieu P., Charuel, Jean‐Luc, Relaix, Fréderic, Bader‐Meunier, Brigitte, Authier, FrançoisJérôme, Gitiaux, Cyril
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2021; Wiley
• Subjects: Abnormalities; Adolescent; Autoantibodies; Autoantibodies - immunology; Biomarkers; Biopsy; Case-Control Studies; Child; Child, Preschool; Children; Correlation; Cytokines - metabolism; DEAD Box Protein 58 - metabolism; Dermatomyositis; Dermatomyositis - diagnosis; Dermatomyositis - metabolism; Dermatomyositis - physiopathology; Diagnosis; Duchenne's muscular dystrophy; Dystrophy; Female; Humans; Immunoblotting; Immunohistochemistry; Inflammation; Interferon; Interferon-Induced Helicase, IFIH1 - metabolism; Life Sciences; Male; Melanoma; Motor task performance; Muscle strength; Muscle, Skeletal - metabolism; Muscular dystrophy; Muscular Dystrophy, Duchenne - metabolism; Myopathies, Structural, Congenital - metabolism; Myositis; Myositis - diagnosis; Myositis - metabolism; Myositis - physiopathology; Polymerase chain reaction; Prognosis; Proteins; Real-Time Polymerase Chain Reaction; Receptors, Immunologic - metabolism; Regulation; Strength testing; Subgroups; Ubiquitin Thiolesterase - metabolism; Ubiquitins - metabolism; USP18 protein

Objective Juvenile idiopathic inflammatory/immune myopathies (IIMs) constitute a highly heterogeneous group of disorders with diagnostic difficulties and prognostic uncertainties. Circulating myositis‐specific autoantibodies (MSAs) have been recognized as reliable tools for patient substratification...