Lower Circulating Folate Induced by a Fidgetin Intronic Variant is Associated with Reduced Congenital Heart Disease Susceptibility - Wang, Dan; Wang, Feng; Shi, Kai-Hu; Tao, Hui; Li, Yang; Zhao, Rui; Lu, Han; Duan, Wenyuan; Qiao, Bin; Zhao, Shi-Min; Wang, Hongyan; Zhao, Jian-Yuan (Circulation (New York, N.Y.), 2017)
Keywords: Adenosine Triphosphatases - genetics; Adenosine Triphosphatases - metabolism; Animals; Asian Continental Ancestry Group - genetics; ATPases Associated with Diverse Cellular Activities; Biomarkers - blood; Case-Control Studies; Chi-Square Distribution; Child, Preschool; China - epidemiology; Cyclic AMP Response Element-Binding Protein - genetics; Cyclic AMP Response Element-Binding Protein - metabolism; Down-Regulation; Female; Folic Acid - blood; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Heart Defects, Congenital - diagnosis; Heart Defects, Congenital - ethnology; Heart Defects, Congenital - genetics; Heart Defects, Congenital - prevention & control; HEK293 Cells; Heterozygote; Homozygote; Humans; Introns; Logistic Models; Male; Membrane Transport Proteins - metabolism; Microtubule-Associated Proteins; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex - metabolism; Protective Factors; Proteolysis; Rats; Risk Assessment; Risk Factors; RNA Interference; Tetrahydrofolate Dehydrogenase - metabolism; Transcription, Genetic; Transfection; folate utilization; proteasome; folate transmembrane transport; congenital heart diseases