The Involvement of Danger-Associated Molecular Patterns in the Development of Immunoparalysis in Cardiac Arrest Patients

• Published in: Critical care medicine Vol. 43; no. 11; p. 2332
• Main Authors: Timmermans, Kim, Kox, Matthijs, Gerretsen, Jelle, Peters, Esther, Scheffer, Gert Jan, van der Hoeven, Johannes G, Pickkers, Peter, Hoedemaekers, Cornelia W
• Format: Journal Article
• Language: English
• Published: United States 01.11.2015
• Subjects: Academic Medical Centers; Adult; Age Factors; Aged; Analysis of Variance; Biomarkers - blood; Cardiopulmonary Resuscitation - methods; Case-Control Studies; Critical Care - methods; Critical Illness - mortality; Critical Illness - therapy; Cytokines - blood; Female; Hospital Mortality - trends; Humans; Hypothermia, Induced - adverse effects; Hypothermia, Induced - methods; Immune Tolerance; Intensive Care Units; Interleukin-10 - blood; Interleukin-6 - blood; Male; Membrane Proteins - blood; Middle Aged; Netherlands; Out-of-Hospital Cardiac Arrest - blood; Out-of-Hospital Cardiac Arrest - mortality; Out-of-Hospital Cardiac Arrest - therapy; Prospective Studies; Real-Time Polymerase Chain Reaction; Reference Values; Respiration, Artificial - methods; Sex Factors; Statistics, Nonparametric; Survival Rate; Netherlands

After cardiac arrest, patients are highly vulnerable toward infections, possibly due to a suppressed state of the immune system called "immunoparalysis." We investigated if immunoparalysis develops following cardiac arrest and whether the release of danger-associated molecular patterns cou...