Distribution, characterization and significance of polyomavirus genomic sequences in tumors of the brain and its covering

• Published in: Journal of medical virology Vol. 77; no. 3; pp. 447 - 454
• Main Authors: Delbue, Serena, Pagani, Elisabetta, Guerini, Franca R., Agliardi, Cristina, Mancuso, Roberta, Borghi, Elisa, Rossi, Francesca, Boldorini, Renzo, Veggiani, Claudia, Car, Pier Giorgio, Ferrante, Pasquale
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2005; Wiley-Liss
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biopsy; BK virus; BK Virus - classification; BK Virus - genetics; BK Virus - isolation & purification; brain neoplasia; Brain Neoplasms - surgery; Brain Neoplasms - virology; DNA, Viral - genetics; DNA, Viral - isolation & purification; Female; Fundamental and applied biological sciences. Psychology; Genome, Viral; Genotype; Human viral diseases; Humans; Infectious diseases; JC virus; JC Virus - classification; JC Virus - genetics; JC Virus - isolation & purification; large T antigen; Male; Medical sciences; Meningioma - surgery; Meningioma - virology; Microbiology; Middle Aged; Miscellaneous; Polyomavirus; Polyomavirus Infections - surgery; Polyomavirus Infections - virology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; Sequence Analysis, DNA; Simian virus 40; transcriptional control region TCR; Tumor Virus Infections - surgery; Tumor Virus Infections - virology; Viral diseases; viral protein 1 VP1; Virology; Nervous system diseases; T cell receptor; Genomics; Polyomavirus; transcriptional control region TCR; Papovaviridae; Intracranial tumor; viral protein 1 VP1; Protein; Cerebral disorder; Infection; Virus; JC virus; Viral disease; Central nervous system disease; Large T antigen; brain neoplasia

The etiology of brain tumors and meningiomas is still unknown. Several factors have been considered, such as genetic predisposition and environmental risk factors, but the hypothesis that one or more infectious agents may play a role in tumor pathogenesis has also been investigated. Therefore, empha...