Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment

• Published in: Clinical pharmacology and therapeutics Vol. 78; no. 4; p. 330
• Main Authors: Lee, Edmund, Ryan, Stephen, Birmingham, Bruce, Zalikowski, Julie, March, Ruth, Ambrose, Helen, Moore, Rachael, Lee, Caroline, Chen, Yusong, Schneck, Dennis
• Format: Journal Article
• Language: English
• Published: United States 01.10.2005
• Subjects: Adult; Area Under Curve; Asian Continental Ancestry Group - genetics; Diet; Environment; European Continental Ancestry Group - genetics; Female; Fluorobenzenes - blood; Fluorobenzenes - pharmacokinetics; Gene Frequency; Genotype; Half-Life; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics; Male; Organic Anion Transporters - genetics; Polymorphism, Single Nucleotide; Prospective Studies; Pyrimidines - blood; Pyrimidines - pharmacokinetics; Rosuvastatin Calcium; Singapore; Solute Carrier Organic Anion Transporter Family Member 1b1; Sulfonamides - blood; Sulfonamides - pharmacokinetics

Systemic exposure to rosuvastatin had been observed to be approximately 2-fold higher in Japanese subjects living in Japan compared with white subjects in Western Europe or the United States. The organic anion transporting polypeptide 1B1 contributes to the hepatic uptake of rosuvastatin. Polymorphi...