Intermittent Hypoxia Causes Inflammation and Injury to Human Adult Cardiac Myocytes

• Published in: Anesthesia and analgesia Vol. 122; no. 2; pp. 373 - 380
• Main Authors: Wu, Jing, Stefaniak, Joanna, Hafner, Christina, Schramel, Johannes Peter, Kaun, Christoph, Wojta, Johann, Ullrich, Roman, Tretter, Verena Eva, Markstaller, Klaus, Klein, Klaus Ulrich
• Format: Journal Article
• Language: English
• Published: United States International Anesthesia Research Society 01.02.2016
• Subjects: Adult; Bioreactors; Cell Proliferation; Cells, Cultured; Cytokines - metabolism; Gene Expression; Humans; Hypoxia - complications; Hypoxia - genetics; Hypoxia - pathology; L-Lactate Dehydrogenase - metabolism; Membranes, Artificial; Myocarditis - etiology; Myocarditis - genetics; Myocarditis - pathology; Myocytes, Cardiac - pathology; Signal Transduction; Sleep Apnea, Obstructive - pathology; Vascular Endothelial Growth Factor A - metabolism

BACKGROUND:Intermittent hypoxia may occur in a number of clinical scenarios, including interruption of myocardial blood flow or breathing disorders such as obstructive sleep apnea. Although intermittent hypoxia has been linked to cardiovascular and cerebrovascular disease, the effect of intermittent...