Adoption of Universal Testing in Endometrial Cancers for Microsatellite Instability Using Next-Generation Sequencing

• Published in: JCO precision oncology Vol. 7; p. e2300033
• Main Authors: Rodriguez, Isabel V, Strickland, Sarah, Wells, David, Manhardt, Enna, Konnick, Eric Q, Garcia, Rochelle, Swisher, Elizabeth, Kilgore, Mark, Norquist, Barbara
• Format: Journal Article
• Language: English
• Published: United States 01.09.2023
• Subjects: Colorectal Neoplasms, Hereditary Nonpolyposis - genetics; Endometrial Neoplasms - diagnosis; Endometrial Neoplasms - genetics; Female; Genetic Testing; High-Throughput Nucleotide Sequencing; Humans; Microsatellite Instability; Mutation

To assess implementation of a next-generation sequencing (NGS) assay to detect microsatellite instability (MSI) as a screen for Lynch syndrome (LS) in endometrial cancer (EC), while determining and comparing characteristics of the four molecular subtypes. A retrospective review was performed of 408...