Parkinson Disease and Subthalamic Nucleus Deep Brain Stimulation: Cognitive Effects in GBA Mutation Carriers

• Published in: Annals of neurology Vol. 91; no. 3; pp. 424 - 435
• Main Authors: Pal, Gian, Mangone, Graziella, Hill, Emily J., Ouyang, Bichun, Liu, Yuanqing, Lythe, Vanessa, Ehrlich, Debra, Saunders‐Pullman, Rachel, Shanker, Vicki, Bressman, Susan, Alcalay, Roy N., Garcia, Priscilla, Marder, Karen S., Aasly, Jan, Mouradian, M. Maral, Link, Samantha, Rosenbaum, Marc, Anderson, Sharlet, Bernard, Bryan, Wilson, Robert, Stebbins, Glenn, Nichols, William C., Welter, Marie‐Laure, Sani, Sepehr, Afshari, Mitra, Verhagen, Leo, Bie, Rob M.A., Foltynie, Tom, Hall, Deborah, Corvol, Jean‐Christophe, Goetz, Christopher G.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2022; Wiley Subscription Services, Inc; Wiley
• Subjects: Aged; Brain; Cognition; Cognition & reasoning; Cognition - physiology; Cognitive ability; Confidence intervals; Databases, Factual; Decision making; Deep Brain Stimulation; Deep Brain Stimulation - methods; Dementia disorders; Electrical stimuli; Female; Glucosylceramidase; Glucosylceramidase - genetics; Heterozygote; Humans; Life Sciences; Male; Middle Aged; Movement disorders; Mutation; Neurodegenerative diseases; Neurons and Cognition; Neuropsychological Tests; Parkinson Disease; Parkinson Disease - genetics; Parkinson Disease - physiopathology; Parkinson Disease - psychology; Parkinson Disease - therapy; Parkinson's disease; Solitary tract nucleus; Stimulation; Subthalamic Nucleus; Subthalamic Nucleus - physiopathology
• ISSN: 0364-5134; 1531-8249; 1531-8249
• DOI: 10.1002/ana.26302

Objective This study was undertaken to compare the rate of change in cognition between glucocerebrosidase (GBA) mutation carriers and noncarriers with and without subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson disease. Methods Clinical and genetic data from 12 datasets were examin...