LKB1 signaling is activated in CTNNB1‐mutated HCC and positively regulates β‐catenin‐dependent CTNNB1‐mutated HCC

• Published in: The Journal of pathology Vol. 247; no. 4; pp. 435 - 443
• Main Authors: Charawi, Sara, Just, Pierre‐Alexandre, Savall, Mathilde, Abitbol, Shirley, Traore, Massiré, Metzger, Nolwenn, Ravinger, Roland, Cavard, Catherine, Terris, Benoit, Perret, Christine
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.04.2019; Wiley Subscription Services, Inc; Wiley
• Subjects: Animals; beta Catenin - physiology; Biochemistry, Molecular Biology; Cancer; Carcinoma, Hepatocellular - genetics; Catenin; Clonal deletion; CTNNB1; Energy metabolism; Epistasis; Gene Deletion; Gene Knockdown Techniques; Genomics; Genotype & phenotype; Hepatocellular carcinoma; Hepatoma; Heterogeneity; Humans; Life Sciences; Liver; Liver cancer; Liver Neoplasms - genetics; LKB1; LKB1 protein; Metabolism; Mice; Mutation - genetics; Phenotypes; Polarity; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Protein-Serine-Threonine Kinases - physiology; Transcription; Transfection - methods; Tumor Cells, Cultured; Tumorigenesis; Wnt protein; Wnt Signaling Pathway - physiology; Zonation; CTNNB1; liver; LKB1; hepatocellular carcinoma

Hepatocellular carcinomas (HCCs) are known to be highly heterogenous. Within the extensive histopathological and molecular heterogeneity of HCC, tumors with mutations in CTNNB1, encoding β‐catenin (CTNNB1‐mutated HCC), constitute a very homogeneous group. We previously characterized a distinctive me...