A shared promoter region suggests a common ancestor for the human VCX/Y, SPANX, and CSAG gene families and the murine CYPT family

• Published in: Molecular reproduction and development Vol. 75; no. 2; pp. 219 - 229
• Main Authors: Hansen, Martin A., Nielsen, John E., Retelska, Dorota, Larsen, Niels, Leffers, Henrik
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2008; Wiley-Liss
• Subjects: Amino Acid Sequence; Animals; Antigens, Neoplasm - genetics; Base Sequence; Biological and medical sciences; Conserved Sequence; DNA Primers; Evolution; Evolution, Molecular; Evolutionary genetics; Expressed Sequence Tags; Fundamental and applied biological sciences. Psychology; Gene conversion; Gene expression; Gene families; Genomes; genomics; Germ cells; Homology; Hormone metabolism and regulation; Humans; Mammalian male genital system; Mice; Molecular Sequence Data; Multigene Family; Neoplasm Proteins - genetics; Nuclear Proteins - genetics; Pachytene; promoter; Promoter Regions, Genetic; Promoters; Protein structure; Proteins - genetics; Sex chromosomes; Somatic cells; Spermatids; Spermatocytes; spermatogenesis; testis; Vertebrates: reproduction; Human; Spermatogenesis; Rodentia; evolution; testis; Gene expression; Testicle; Male genital system; Promoter; Vertebrata; Mammalia; Mouse; Localization; Comparative study

Many testis‐specific genes from the sex chromosomes are subject to rapid evolution, which can make it difficult to identify murine genes in the human genome. The murine CYPT gene family includes 15 members, but orthologs were undetectable in the human genome. However, using refined homology search,...