Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients

• Published in: Journal of traumatic stress Vol. 20; no. 6; pp. 923 - 932
• Main Authors: Stein, Murray B., Kerridge, Carol, Dimsdale, Joel E., Hoyt, David B.
• Format: Journal Article
• Language: English
• Published: Germantown Wiley Subscription Services, Inc., A Wiley Company 01.12.2007; Wiley
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Amines - administration & dosage; Amines - therapeutic use; Anti-Anxiety Agents - administration & dosage; Anti-Anxiety Agents - therapeutic use; Anxiety disorders. Neuroses; Biological and medical sciences; California; Cyclohexanecarboxylic Acids - administration & dosage; Cyclohexanecarboxylic Acids - therapeutic use; Female; gamma-Aminobutyric Acid - administration & dosage; gamma-Aminobutyric Acid - therapeutic use; Humans; Male; Medical sciences; Middle Aged; Placebos; Post-traumatic stress disorder; Propranolol - administration & dosage; Propranolol - therapeutic use; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Stress Disorders, Post-Traumatic - prevention & control; Vasodilator Agents - administration & dosage; Vasodilator Agents - therapeutic use; Wounds and Injuries - drug therapy; Wounds and Injuries - psychology; California; Human; Chemotherapy; Treatment; Posttraumatic syndrome; Anxiety disorder; Pharmacotherapy; Posttraumatic stress disorder; Physical injury; Stress

Acute physical injury is frequently associated with mental health sequelae, which then accentuate disability and worsen functional outcomes. A pharmacological prevention approach to this problem has been proposed. This proof‐of‐concept study was a double‐blind, randomized controlled trial of 14 days...