Commercial assays for serum osteocalcin give clinically discordant results

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 40; no. 3; pp. 358 - 363
• Main Authors: Masters, PW, Jones, RG, Purves, DA, Cooper, EH, Cooney, JM
• Format: Journal Article
• Language: English
• Published: Washington, DC Am Assoc Clin Chem 01.03.1994; American Association for Clinical Chemistry
• Subjects: Adult; Aged; Analysis of complex biological substances; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Blood and biological fluids; Female; Fundamental and applied biological sciences. Psychology; Glucocorticoids - therapeutic use; Humans; Hyperparathyroidism - blood; Immunoradiometric Assay - standards; Immunoradiometric Assay - statistics & numerical data; Male; Middle Aged; Osteitis Deformans - blood; Osteocalcin - blood; Osteoporosis, Postmenopausal - blood; Pregnancy; Radioimmunoassay - standards; Radioimmunoassay - statistics & numerical data; Reagent Kits, Diagnostic - standards; Reagent Kits, Diagnostic - statistics & numerical data; Renal Insufficiency - blood; Biological fluid; Osteoporosis; Serum; Osteocalcin; Analysis method

Serum samples from 9 healthy controls and from subjects with primary hyperparathyroidism (n = 5), Paget disease (n = 3), pregnancy (n = 5), glucocorticoid therapy (n = 5), postmenopausal osteoporosis (n = 10), and renal failure (n = 10) were used to assess the clinical agreement among eight commerci...