Stability prediction of canonical and non-canonical structures of nucleic acids in various molecular environments and cells

• Published in: Chemical Society reviews Vol. 49; no. 23; pp. 8439 - 8468
• Main Authors: Takahashi, Shuntaro, Sugimoto, Naoki
• Format: Journal Article
• Language: English
• Published: London Royal Society of Chemistry 07.12.2020
• Subjects: Acids; Crowding; Deoxyribonucleic acid; DNA; Gene expression; Nucleic acids; Predictions

Nucleic acids (DNA and RNA) dynamically fold and unfold to exert their functions in cells. These folding and unfolding behaviours are also the basis for various technical applications. To understand the biological mechanism of nucleic acid function, and design active materials using nucleic acids, b...