Uterine leiomyoblastoma

• Published in: BMJ case reports Vol. 14; no. 2; p. e241533
• Main Authors: Mulita, Francesk, Iliopoulos, Fotios, Plachouri, Kerasia-Maria, Kehagias, Ioannis
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 18.02.2021; BMJ Publishing Group
• Subjects: Case reports; Female; Fibroids; Gynecology; Histopathology; Humans; Hysterectomy; Images In; Leiomyoma, Epithelioid; Obstetrics; Smooth muscle; Tumors; Uterine cancer; Uterus; general surgery; obstetrics and gynaecology
• ISSN: 1757-790X; 1757-790X
• DOI: 10.1136/bcr-2020-241533

Pelvis MRI was performed and confirmed an intramural International Federation of Gynecology and Obstetrics (FIGO)-type 6, homogenous and hypointense solid uterine tumour 11×8×6.5 cm with dilated blood vessels measuring up to 6 mm in diameter (figure 1A,B). Microscopically, epithelioid leiomyomas consist of sheets or groups of round or polygonal cells with eosinophilic or clear cytoplasm, which mainly contain cytolysosomes, glycogen aggregates and αSMA myofilaments.2 The tumour’s immunophenotype is distinct from typical epithelioid leiomyomas, as its cells are negative for desmin and h-caldesmon while positive for keratins and histone deacetylase 8—a marker of smooth muscle differentiation.4 The gold standard treatment of clear cell type epithelioid leiomyoma is identical to that of the typical leiomyoma and consists of total hysterectomy. [...]neoplasms with one or more of the features such as 2–4 mitoses/10 HPF, size greater than 6 cm, necrosis and moderate or worse cytological atypia are classified as uterine smooth muscle tumours of unknown malignant potential and necessitate a careful follow-up.5 6 Learning points Uterine leiomyoblastomas are rare uterine tumours that are usually found incidentally on surgical operations because of other pathology.