Novel STAT3 Inhibitor LDOC1 Targets Phospho-JAK2 for Degradation by Interacting with LNX1 and Regulates the Aggressiveness of Lung Cancer

• Published in: Cancers Vol. 11; no. 1; p. 63
• Main Authors: Lee, Chia-Huei, Yang, Ji-Rui, Chen, Chih-Yu, Tsai, Ming-Hsien, Hung, Pin-Feng, Chen, Shin-Jih, Chiang, Shang-Lun, Chang, Han, Lin, Pinpin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.01.2019; MDPI
• Subjects: Adenocarcinoma; Cell cycle; Cigarette smoke; Cigarettes; Confocal microscopy; DNA methylation; Gene expression; Immunohistochemistry; Immunoprecipitation; Interleukin 6; Janus kinase 2; Leucine zipper proteins; Lung cancer; Lung carcinoma; Malignancy; Medical prognosis; Non-small cell lung carcinoma; Patients; Phenotypes; Phosphorylation; Proteasomes; Proteins; Stat3 protein; Tumor cell lines; Tumorigenesis; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination; lung cancer; LNX1; LDOC1; JAK2; ubiquitination; STAT3

Meta-analysis revealed that Leucine Zipper Down-Regulated In Cancer 1 (LDOC1) increased methylation more in people with lung tumors than in those who were healthy and never smoked. Quantitative methylation-specific PCR revealed that cigarette smoke condensate (CSC) exposure drives LDOC1 promoter hyp...