MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations

• Published in: Neurology Vol. 73; no. 4; p. 287
• Main Authors: Vemuri, P, Wiste, H J, Weigand, S D, Shaw, L M, Trojanowski, J Q, Weiner, M W, Knopman, D S, Petersen, R C, Jack, Jr, C R
• Format: Journal Article
• Language: English
• Published: United States 28.07.2009
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - analysis; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers - analysis; Biomarkers - cerebrospinal fluid; Brain - metabolism; Brain - pathology; Brain - physiopathology; Cognition - physiology; Cognition Disorders - cerebrospinal fluid; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Cohort Studies; Cross-Sectional Studies; Diagnosis, Differential; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Tissue Proteins - analysis; Nerve Tissue Proteins - cerebrospinal fluid; Neuropsychological Tests; Predictive Value of Tests; Reference Values; Severity of Illness Index; tau Proteins - analysis; tau Proteins - cerebrospinal fluid

To assess the correlations of both MRI and CSF biomarkers with clinical diagnosis and with cognitive performance in cognitively normal (CN) subjects and patients with amnestic mild cognitive impairment (aMCI) and Alzheimer disease (AD). This is a cross-sectional study with data from the Alzheimer�...