Correlation Between ENPP1 Gene rs1044498 Polymorphism with the Risk of Type 2 Diabetes Mellitus: A Meta-analysis

• Published in: The Tohoku Journal of Experimental Medicine Vol. 266; no. 1; pp. 19 - 28
• Main Authors: Liu, Li, Li, Chunlin
• Format: Journal Article
• Language: English
• Published: Japan Tohoku University Medical Press 2025
• Subjects: Diabetes Mellitus, Type 2 - genetics; ENPP1; Genetic Association Studies; Genetic Predisposition to Disease; Humans; meta-analysis; Phosphoric Diester Hydrolases - genetics; Polymorphism, Single Nucleotide - genetics; Publication Bias; Pyrophosphatases - genetics; Risk Factors; rs1044498; type 2 diabetes mellitus; meta-analysis; type 2 diabetes mellitus; ENPP1; rs1044498

As a common metabolic disease, type 2 diabetes mellitus (T2DM) is regulated by the ectoenzyme nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1). A functional polymorphism of ENPP1 (rs1044498, K121Q) has been found to contribute to T2DM susceptibility. This study aims to analyze the combined ass...