DUSP10 Is a Regulator of YAP1 Activity Promoting Cell Proliferation and Colorectal Cancer Progression

• Published in: Cancers Vol. 11; no. 11; p. 1767
• Main Authors: Jiménez-Martínez, Marta, Ostalé, Cristina M, van der Burg, Lennart R, Galán-Martínez, Javier, Hardwick, James C H, López-Pérez, Ricardo, Hawinkels, Lukas J A C, Stamatakis, Konstantinos, Fresno, Manuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.11.2019; MDPI
• Subjects: Cancer; Cell density; Cell growth; Cell proliferation; Colorectal cancer; Colorectal carcinoma; Contact inhibition; Cytoplasm; Dephosphorylation; Kinases; Localization; Medical prognosis; Phenotypes; Phosphatase; Phosphorylation; Plasmids; Proteins; Xenografts; Yes-associated protein; cancer; cell proliferation; prognosis; cell contact inhibition; protein

Cell contact inhibition (CCI) is deregulated in cancer. Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. We found that dual-specificity phosphatase 10 (DUSP10) is involved in CRC. DUSP10 overexpression increased the growth of CRC cell lines and mouse xenografts, while t...