Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites - Guo, Hao; Chou, Wei-Chun; Lai, Yunjia; Liang, Kaixin; Tam, Jason W.; Brickey, W. June; Chen, Liang; Montgomery, Nathan D.; Li, Xin; Bohannon, Lauren M.; Sung, Anthony D.; Chao, Nelson J.; et al. (Science (American Association for the Advancement of Science), 2020)
Keywords: Abundance; Acute Radiation Syndrome - microbiology; Acute Radiation Syndrome - prevention & control; Acute Radiation Syndrome - therapy; Animals; Attenuation; Bacteria; Biocompatibility; Clostridiales - metabolism; Colitis; Correlation analysis; Cytokines; Digestive system; Disorders; DNA damage; Dysbacteriosis; Enterococcaceae - metabolism; Fatty acids; Fatty Acids, Volatile - metabolism; Fatty Acids, Volatile - therapeutic use; Gastrointestinal diseases; Gastrointestinal Microbiome; Gastrointestinal tract; Germfree; Hematopoiesis; Humans; Indoles; Inflammation; Interferon; Interleukin 6; Intestinal microflora; Intestine; Ionizing radiation; Kynurenic acid; Lachnospiraceae; Leukemia; Life span; Metabolites; Metabolomics; Mice; Mice, Inbred C57BL; Microbiota; Microorganisms; Niches; Obesity; Patients; Radiation; Radiation damage; Radiation dosage; Radiation effects; Radiation injuries; Radiation Protection; Radiation therapy; Radiation tolerance; Reactive oxygen species; Side effects; Signs and symptoms; Statistical analysis; Survival; Survivors; Toxicity; Tryptophan - metabolism; γ-Interferon