Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells - Mateus, Jose; Dan, Jennifer M.; Zhang, Zeli; Rydyznski Moderbacher, Carolyn; Lammers, Marshall; Goodwin, Benjamin; Sette, Alessandro; Crotty, Shane; Weiskopf, Daniela (Science (American Association for the Advancement of Science), 2021)
Keywords: 2019-nCoV Vaccine mRNA-1273; Adolescent; Adult; Age; Age differences; Aged; Aged, 80 and over; Antibodies; Antibodies, Viral - blood; Antiviral drugs; Between-subjects design; Binding; Blood; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Clinical trials; Clinical Trials, Phase I as Topic; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Cross Reactions; Dosage; Durability; Equivalence; Feedback (Response); Helper cells; Humans; Immunity; Immunization; Immunogenicity, Vaccine; Immunologic Memory; Immunological memory; Immunology; Infections; Interferon; Longitudinal Studies; Lymphocytes; Lymphocytes T; Memory; Memory cells; Middle Aged; mRNA; mRNA vaccines; Neutralizing; Patients; Questions; Respiratory diseases; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - immunology; Vaccination; Vaccines; Viral diseases; Young Adult; γ-Interferon